Lizzo, Billie Eilish and Sir Elton John will perform at a TV concert curated by Lady Gaga, which will celebrate health workers amid the coronavirus crisis.
Gaga, along with the group Global Citizen, has already raised $35m (£28m) for the World Health Organisation.
The funds will buy protective equipment for health workers and support efforts to develop drugs and vaccines.
Gaga also announced she had co-curated a concert to recognise health workers’ efforts in fighting Covid-19.
One World: Together at Home, which will also feature Sir Paul McCartney and Stevie Wonder, will be live-streamed in the US and screened on BBC One in the UK.
Hosted by US talk show hosts Jimmy Fallon, Jimmy Kimmel and Stephen Colbert, One World: Together at Home will go out on 18 April across TV networks in the US.